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Therapy with implantable devices: ICD, CRT, LBBA pacing

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Therapy with implantable devices: ICD, CRT, LBBA pacing

Terminology

  • ICD = implantable cardioverter – defibrillator.
  • CRT = cardiac resynchronization therapy.
  • CRT-P = cardiac resynchronization therapy with pacemaker function only.
  • CRT-D = cardiac resynchronization therapy with also defibrillator function (possibility of electrical antitachytherapy (antitachypacing and/or defibrillation) for persistent ventricular arrhythmias).
  • LBTB = left bundle branch block
  • LBBA pacing = left bundle branch area pacing (conduction pacemaker)
  • VT / VF = ventricular tachycardia / ventricular fibrillation
  • SVT = supraventricular tachycardia
  • RA = right atrium
  • RV = right ventricle
  • LV = left ventricle

Mechanism of action

CRT :

Improvement of the function of the LV by resynchronization of the electrical activation of all segments of the myocardium in the LV.

  • In certain patients with heart failure there is a significant slowing of electrical conduction in the LV. This is manifested by a bundle branch block (QRS > 120 ms). Particularly in left bundle branch block, this causes asynchronous contraction of the LV with an early, weak contraction of the septum and a later contraction of the lateral wall. Because these segments do not contract simultaneously (synchronously), a lot of energy is lost and the pumping function of the LV decreases with progressive LV dilation and decrease in LVEF.
  • With CRT, 3 leads are usually implanted (one in the RA, one in the RV and one additional lead to the posterolateral wall of the LV via the coronary sinus). By pacing on RV and LV leads, simultaneous (synchronous) activation and contraction of all segments of the LV is aimed for. This increases cardiac output and pump function in good responders (decrease in LV volume and improvement in LVEF).
  • If CRT implantation is not successful, an LBBA pacemaker or conduction pacemaker can be placed as an alternative. By pacing in the left bundle branch in the interventricular septum, the electrical activation of the LV occurs faster, with a narrower QRS and less LV dyssynchrony. However, it has not yet been proven whether the results of long-term therapy are equivalent to the effects of CRT in HFrEF.
CRT-D device met 3 leads: 1. Rechter atrium, 2. Rechter ventrikel, 3. Linker ventrikel (via de sinus coronarius).
CRT-D device with 3 leads: 1. Right atrium, 2. Right ventricle, 3. Left ventricle (via the coronary sinus).
CRT-D device met 2 leads: 1. Rechter atrium: alleen sensing (in de RV lead), 2. Rechter ventrikel, 3. Linker ventrikel (heelkundig epicardiaal geplaatst).
CRT-D device with 2 leads: 1. Right atrium: sensing pole only (in the RV lead), 2. Right ventricle, 3. Left ventricle (surgically placed epicardially).

ICD:

Prevention of sudden death by automatic rapid detection and attempted termination of ventricular arrhythmias (VT/ VF) with an internal electric shock. In bradycardia, an ICD will stimulate the heart like a pacemaker.

  • VVI-ICD: Only 1 shock lead is implanted in the RV.
  • DDD-ICD: 2 leads are implanted. One in the RA and one in the RV. The atrial lead allows for atrial pacing and better detection of AF. This also allows better discrimination between SVT and VT.
  • S-ICD, subcutaneous ICD: the device and shock lead are implanted completely extravascular (subcutaneous).
VVI-ICD. Er is maar 1 lead tot in het rechter ventrikel. Het verdikte, dense deel van de lead is de coil waarlangs een shock kan gegeven bij een significante tachycardie.
VVI-ICD. There is only 1 lead into the right ventricle. The thickened, dense part of the lead is the coil through which a shock can be delivered in the event of significant tachycardia.

Expected beneficial effects in heart failure

CRT :

  • Increase in cardiac output and hemodynamic improvement. Increase in LVEF.
  • Reduction of sympathetic activity.
  • Reduction of RAAS activation.
  • Reduction of cardiac arrhythmias and sudden death (even without ICD function) by, among other things, improving LV function. With better LVEF there is a lower risk of VT or VF. CRT pacing also prevents symptomatic bradycardia and sinus arrest or asystole.

ICD:

  • Reduction of sudden death due to cardiac arrhythmias.
  • An ICD has no effect on heart function and therefore has no effect on the symptoms of heart failure or on hospitalizations for heart failure.

Proven effects

CRT :

Trials: MIRACLE, COMPANION, CARE-HF, REVERSE, MADIT-CRT, RAFT

  • Reduction of all-cause and cardiovascular mortality
  • Reduction of hospitalizations for heart failure
  • Reduction of symptoms and improvement of quality of life
  • Reduction of arrhythmias and sudden death
  • Improvement of LVEF

ICD:

Trials: MADIT, MADIT-II, DEFINITE, SCD-HeFT

  • Reduction of all-cause and cardiovascular mortality, especially in patients with HFrEF due to an ischemic cardiomyopathy and with few symptoms (NYHA II).

Indications

CRT :

HFrEF with an LVEF ≤ 35% and symptomatic heart failure (NYHA II or III) despite optimal drug treatment and one of the following situations:

There is a strict indication for CRT if:

  • Left bundle branch block (LBTB) with QRS ≥ 150 ms and sinus rhythm.
  • Pacemaker indication due to AV block, where a high ventricular pacing percentage is expected.

CRT is also strongly considered if:

  • LBTB with QRS 130-149 ms and sinus rhythm.
  • Right or non-specific bundle branch block with QRS ≥ 150 ms and sinus rhythm.
  • Progressive HFrEF after implantation of a classical pacemaker due to a high percentage of RV pacing. This is an upgrade from a pacemaker to a CRT.

In patients with AF as the underlying heart rhythm, the results with CRT are less convincing. If the QRS is ≥ 150 ms and especially if the QRS has a left bundle branch block morphology, it is best to try CRT, provided maximum pharmacological blockade of the atrioventricular conduction to achieve a high ventricular pacing percentage. If this is not pharmacologically successful (with beta-blocker, digoxin, amiodarone), His-Bundle ablation can be done.

ICD:

Secondary prevention of sudden death: 

This is prevention of sudden death after an event such as:

1) Survival 'sudden cardiac death' (SCD) due to VT or VF after successful resuscitation, if NOT provoked by an acute myocardial infarction or by a reversible cause (electrolyte disturbance, drugs, trauma).

2) Syncope or abrupt presyncope + spontaneous documented non-sustained or sustained VT with:

  • with underlying structural heart disease
  • without underlying structural heart disease, but not suitable for other therapy (explicitly state the reason why medication or ablation is not possible).

3) Syncope without documented tachyarrhythmia in patients with structural heart disease + inducible sustained VT/VF during EFO.

 

Primary prevention of sudden death:

This is a preventive implantation of an ICD without ever having previously documented an event or serious ventricular arrhythmia in a patient with underlying chronic severe heart disease with an increased risk of sudden death, such as:

  • ischemic cardiomyopathy, without revascularizable ischemia, at least 40 days after an acute myocardial infarction or more than 3 months after successful revascularization and persistent:
    • LVEF ≤ 30% + NYHA class I
    • LVEF ≤ 35% + NYHA class II or III
    • LVEF ≤ 40% + spontaneous non-sustained VT + inducible sustained VT/VF during EFO
  • non-ischemic cardiomyopathy with LVEF ≤ 35% + NYHA class II - III despite optimal heart failure therapy for more than 3 months. The prognostic benefits are less significant than in patients with ischemic cardiomyopathy.
  • Familial or genetic condition with a known associated risk of ventricular arrhythmias, and an increased risk of sudden death for the patient in question based on internationally accepted risk stratification (long QT syndrome, Brugada syndrome, hypertrophic cardiomyopathy, arrhythmogenic right ventricular dysplasia,... ).

And an expected life expectancy of more than 1 year in a good general, functional condition.

Contraindications

CRT :

A CRT should not be implanted in:

  • a QRS duration < 130 ms, if there is no AV block and therefore little ventricular pacing is expected.

ICD:

An ICD should not be implanted in:

  • A new, recent diagnosis of HFrEF with only optimal therapy for less than 3 to 6 months. With optimal treatment, LV function can improve again, so that the need for prevention of sudden death may disappear after a few months, making the ICD pointless. (see reversible causes of heart failure)
  • Heart failure due to a recent myocardial infarction < 40 days ago.
  • An expected life expectancy < 1 year due to co-morbidity.
  • A poor general and functional condition.
  • Advanced heart failure, NYHA class IV, refractory to therapy, unless the patient is still a candidate for an LVAD or heart transplant.
  • VT storm, refractory to therapy.
  • Significant psychiatric conditions that could be aggravated by implantation of a device or that could prevent systematic follow-up.
  • End-stage renal disease and dialysis. An ICD has never been able to demonstrate a mortality benefit in this setting.

Fitness to drive after implantation of a device in Belgium

Pacemaker (also CRT-P or conduction pacemaker)

  • group 1 (A3, A, B, B+E) – max. suitable for driving for 3 years : (KB 3/2011)
    • New implant: 1 month unfit to drive
    • PM battery replacement: immediately ready to drive
    • PM lead replacement: 1 month unfit to drive
  • group 2 (C, C+E, D, D+E) – max. suitable for driving for 1 year : (KB 23 March 1998)
    • New implant: unfit to drive for 3 months
    • PM battery replacement: 2 weeks unfit to drive
    • PM lead replacement: 3 months unfit to drive

ICD:

  • group 1 (A3, A, B, B+E) : (KB 3/2011)
    • New implant: 1 month unfit to drive
    • battery replacement: immediately ready to drive
    • lead replacement: unfit to drive for 1 month
    • ICD intervention (shock): 3 months unfit to drive
  • group 2 (C, C+E, D, D+E) : permanently unfit to drive
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