Improvement of the function of the LV by resynchronization of the electrical activation of all segments of the myocardium in the LV.
Prevention of sudden death by automatic rapid detection and attempted termination of ventricular arrhythmias (VT/ VF) with an internal electric shock. In bradycardia, an ICD will stimulate the heart like a pacemaker.
Trials: MIRACLE, COMPANION, CARE-HF, REVERSE, MADIT-CRT, RAFT
Trials: MADIT, MADIT-II, DEFINITE, SCD-HeFT
HFrEF with an LVEF ≤ 35% and symptomatic heart failure (NYHA II or III) despite optimal drug treatment and one of the following situations:
There is a strict indication for CRT if:
CRT is also strongly considered if:
In patients with AF as the underlying heart rhythm, the results with CRT are less convincing. If the QRS is ≥ 150 ms and especially if the QRS has a left bundle branch block morphology, it is best to try CRT, provided maximum pharmacological blockade of the atrioventricular conduction to achieve a high ventricular pacing percentage. If this is not pharmacologically successful (with beta-blocker, digoxin, amiodarone), His-Bundle ablation can be done.
Secondary prevention of sudden death:
This is prevention of sudden death after an event such as:
1) Survival 'sudden cardiac death' (SCD) due to VT or VF after successful resuscitation, if NOT provoked by an acute myocardial infarction or by a reversible cause (electrolyte disturbance, drugs, trauma).
2) Syncope or abrupt presyncope + spontaneous documented non-sustained or sustained VT with:
3) Syncope without documented tachyarrhythmia in patients with structural heart disease + inducible sustained VT/VF during EFO.
Primary prevention of sudden death:
This is a preventive implantation of an ICD without ever having previously documented an event or serious ventricular arrhythmia in a patient with underlying chronic severe heart disease with an increased risk of sudden death, such as:
And an expected life expectancy of more than 1 year in a good general, functional condition.
A CRT should not be implanted in:
An ICD should not be implanted in: