Heart failure is classified into three groups based on the measurement of left ventricular ejection fraction (LVEF). This is the percentage of left ventricular (LV) contents pumped out with each contraction of the LV. This classification determines how each patient should be treated.
Based on evolving understanding, the following classification is used internationally today:
This classification arose historically. The first studies for the treatment of heart failure were conducted in patients with HFrEF. It was shown in these patients that symptoms and prognosis were significantly improved by therapy with ACE inhibitors (or ARB), β-blockers and later mineralocorticoid receptor antagonists (MRA).
In contrast, similar studies with these treatments in patients with HFpEF showed no improvement in prognosis. This indicates important pathophysiological differences between the two phenotypes.
Patients with HFmrEF were much less included in heart failure clinical trials. Smaller studies and subanalyses nevertheless suggest an added value of these therapies (similar to the effect seen in HFrEF patients) from an LVEF < 50%.
In recent years, an additional group was defined: HFimpEF, heart failure with improved ejection fraction.
Depending on the underlying cause, heart failure can be reversible provided correct diagnosis and treatment, with significant improvement in heart function and disappearance of heart failure symptoms. (Reversible versus non-reversible causes of heart failure)
Patients with HFimpEF are those with symptomatic heart failure with a baseline LVEF ≤ 40%, a ≥10 % increase from baseline LVEF, and a second measurement of LVEF > 40%.
Nowadays, we also recognise that patients with a baseline LVEF of 41-49% who have an improved LVEF to ≥50% can be categorised as HFimpEF.
Further research on this subject is in progress and has already shown that when LVEF improves, the prescribed heart failure therapy should not always be interrupted just like that, as deterioration of heart function and progression to symptomatic heart failure may occur afterwards.