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The treatment of heart failure with mildly reduced LVEF (HFmrEF) (LVEF 41-49%)

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The treatment of heart failure with mildly reduced LVEF (HFmrEF) (LVEF 41-49%)

  • Diuretics for signs of fluid retention.
  • Since 2023, there has been a class IA recommendation for initiating SGLT2 inhibitors in patients with heart failure regardless of LVEF, including in patients with HFmrEF.
  • Optimal neurohormonal blockade as in HFrEF can also be considered to improve the prognosis (class IIb recommendation: “can be considered”). Subgroup analysis show that HFmrEF patients are more likely to be regarded as patients with HFrEF and are therefore best treated as such with:
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